Sevick-Muraca Eva M, Houston Jessica P, Gurfinkel Michael
The Photon Migration Laboratory, Texas A&M University, College Station 77845-3122, USA.
Curr Opin Chem Biol. 2002 Oct;6(5):642-50. doi: 10.1016/s1367-5931(02)00356-3.
The deep tissue propagation of near-infrared (NIR) light between 700-900 nm offers new opportunities for diagnostic imaging when employing sensitive detection techniques and NIR excitable fluorescent agents that target and report disease and metabolism. Herein, we highlight approaches for illuminating tissues and monitoring the re-emitted fluorescence for tomographic reconstruction, strategies for developing fluorescent dye constructs, and clinical opportunities for fluorescence-enhanced NIR optical imaging.
当采用敏感检测技术以及靶向并报告疾病与代谢情况的近红外（NIR）可激发荧光剂时，700 - 900纳米近红外光在深层组织中的传播为诊断成像提供了新机遇。在此，我们重点介绍用于照亮组织并监测重发射荧光以进行断层重建的方法、开发荧光染料构建体的策略以及荧光增强近红外光学成像的临床应用机遇。
