Geocadin Romergryko G, Sherman David L, Christian Hansen Hans, Kimura Tetsu, Niedermeyer Ernst, Thakor Nitish V, Hanley Daniel F
Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Resuscitation. 2002 Nov;55(2):193-200. doi: 10.1016/s0300-9572(02)00196-x.
The return of neurological function during the early period after resuscitation from cardiac arrest (CA) has not been evaluated systematically. We report the temporal analysis of EEG bursting pattern during the very early periods after resuscitation.
DESIGN/METHOD: A balanced group of good and poor outcome animals was selected from a population of rats subjected to either 5 or 7 min of asphyxial cardiac arrest (ACA) on the basis of a single criteria: 24 h neurobehavioral function based on the neurodeficit score (NDS). The EEGs of six consecutive good outcome rats (NDS > or = 60) and six consecutive poor outcome rats (NDS < 60) were selected for the study. The EEGs of these animals were given to two EEG examiners who were blinded to the selection process, the experimental conditions and the neurobehavioral recovery. The EEG bursting characteristics, such as rate, peak and duration of bursting were studied.
There was significantly higher EEG bursting in the good outcome animals (P < 0.05) and the burst complexes evolved into continuous activity by 90 min. Lower frequency bursting that persisted and failed to evolve into continuous activity was observed in the poor outcome group.
Increased EEG bursting during first 30-40 min after resuscitation from moderate to severe ACA was observed in rats with good neurological outcome at 24 h. Early EEG bursting patterns may provide additional prognostication after resuscitation from CA.
心脏骤停（CA）复苏后早期神经功能的恢复尚未得到系统评估。我们报告了复苏后极早期脑电图爆发模式的时间分析。
设计/方法：从经历5或7分钟窒息性心脏骤停（ACA）的大鼠群体中，根据单一标准选择一组结局良好和结局不良的动物：基于神经功能缺损评分（NDS）的24小时神经行为功能。选择连续6只结局良好的大鼠（NDS≥60）和连续6只结局不良的大鼠（NDS<60）的脑电图进行研究。将这些动物的脑电图交给两名对选择过程、实验条件和神经行为恢复情况不知情的脑电图检查人员。研究了脑电图的爆发特征，如爆发率、峰值和持续时间。
结局良好的动物脑电图爆发明显更高（P<0.05），到90分钟时爆发复合体演变为持续活动。在结局不良组中观察到较低频率的爆发持续存在且未能演变为持续活动。
在24小时神经功能结局良好的大鼠中，观察到从中度至重度ACA复苏后最初30 - 40分钟脑电图爆发增加。早期脑电图爆发模式可能为CA复苏后提供额外的预后信息。
