De Silva S N T, Weerasuriya N, De Alwis N M W, De Silva M W A, Fernando D J S
Department of Medicine, Faculty of Medical Sciences, University of Sri Jayewardenepura, Gangodawila, Nugegoda, Sri Lanka.
Diabetes Res Clin Pract. 2002 Dec;58(3):173-7. doi: 10.1016/s0168-8227(02)00152-3.
An excess of maternal transmission of Type 2 diabetes mellitus has been reported in Europid populations, but not in South India.
A questionnaire-based survey was carried out in 1000 (502 male) people with Type 2 diabetes to establish whether there is an excess of maternal transmission and familial aggregation in a Sri Lankan population.
Mean age of onset was 47+/-12 (+/-S.D.) years and duration of diabetes was 9+/-7 years. Thirty-seven percent reported parents with diabetes, 46.9% had no parents with diabetes, 16.1% did not know the diabetes status of at least one parent and there was no diabetes in the other. Of the probands, 59.4% had at least one affected relative. When both parents' diabetes status was known and only one was affected, diabetes was more common among mothers (n = 156) than fathers (n = 125) of probands (P < 0.001). A further 54 probands had both parents with diabetes. Mean age of onset and duration of the disease among probands with parental diabetes was 43.1+/-(11.1) and 9.6+/-(6.8). In the previous generation, 21.2% of maternal grandmothers and 17.3% of maternal grandfathers in the maternal diabetes group and 4.8% of maternal grandmothers and 17% of maternal grandfathers in the paternal diabetes group had diabetes. Diabetes in siblings and children was more common in those with mothers who had diabetes (53.8% and 4.5%) when compared with those in whom fathers had diabetes (42.4% and 1.6%) (P < 0.0001 and P < 0.01).
Familial aggregation and excess maternal transmission were observed in people with Type 2 diabetes in Sri Lanka.
据报道，在欧洲人群中，2型糖尿病的母系遗传比例过高，但在印度南部并非如此。
对1000名（502名男性）2型糖尿病患者进行了问卷调查，以确定斯里兰卡人群中是否存在母系遗传比例过高和家族聚集现象。
发病平均年龄为47±12（±标准差）岁，糖尿病病程为9±7年。37%的患者报告父母患有糖尿病，46.9%的患者父母没有糖尿病，16.1%的患者不知道至少一位父母的糖尿病状况，而另一位父母没有糖尿病。在这些先证者中，59.4%至少有一位患病亲属。当父母双方的糖尿病状况都已知且只有一方患病时，先证者的母亲（n = 156）患糖尿病的情况比父亲（n = 125）更为常见（P < 0.001）。另有54名先证者的父母均患有糖尿病。父母患有糖尿病的先证者的发病平均年龄和病程分别为43.1±（11.1）和9.6±（6.8）。在上一代中，母系糖尿病组中21.2%的外祖母和17.3%的外祖父患有糖尿病，父系糖尿病组中4.8%的外祖母和17%的外祖父患有糖尿病。与父亲患有糖尿病的先证者（42.4%和1.6%）相比，母亲患有糖尿病的先证者的兄弟姐妹和子女患糖尿病的情况更为常见（53.8%和4.5%）（P < 0.0001和P < 0.01）。
在斯里兰卡的2型糖尿病患者中观察到了家族聚集现象和母系遗传比例过高的情况。
