Katulanda P, Ranasinghe P, Jayawardena R, Sheriff R, Matthews D R
Diabetes Research Unit, Department of Clinical Medicine, Faculty of Medicine, University of Colombo, Sri Lanka; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, UK.
Diabet Med. 2015 Mar;32(3):314-23. doi: 10.1111/dme.12591. Epub 2014 Nov 27.
To describe the influence of family history on diabetes prevalence and associated metabolic risk factors in a nationally representative sample from Sri Lanka.
A cross sectional national survey was conducted among 5000 adults in Sri Lanka. Family history was evaluated at three levels: (1) parents, (2) grandparents (paternal and maternal) and (3) siblings. A binary-logistic regression analysis controlling for confounders (age, gender, BMI and physical activity) was performed in all patients with 'presence of diabetes' as the dichotomous dependent variable and using family history in father, mother, maternal grandmother/grandfather, paternal grandmother/grandfather, siblings and children as binary independent variables.
The sample size was 4485, mean age was 46.1 ± 15.1 years and 39.5% were males. In all adults, the prevalence of diabetes was significantly higher in patients with a family history (23.0%) than those without (8.2%) (P < 0.001). When family history was present in both parents, the prevalence of diabetes was 32.9%. Presence of a family history significantly increased the risk of diabetes [odds ratio (OR): 3.35, 95% confidence interval (CI): 2.78-4.03], obesity (OR: 2.45, 95% CI: 1.99-2.99), hypertension (OR: 1.25, 95% CI: 1.08-1.45) and metabolic syndrome (OR: 2.28, 95% CI: 1.97-2.63). In all adults, the presence of a family history of diabetes in a father (OR: 1.29, 95% CI: 1.02-1.63), mother (OR: 1.23, 95% CI: 1.11-1.36), paternal grandfather (OR: 1.27, 95% CI: 1.14-1.41), siblings (OR: 4.18, 95% CI: 3.34-5.22) and children (OR: 5.47, 95% CI: 2.93-10.19) was associated with a significantly increased risk of developing diabetes.
Family history and diabetes had a graded association in the Sri Lankan population, because the prevalence increased with the increasing number of generations affected. Family history of diabetes was also associated with the prevalence of obesity, metabolic syndrome and hypertension. Individuals with a family history of diabetes form an easily identifiable group who may benefit from targeted interventions.
描述家族史对来自斯里兰卡的具有全国代表性样本中糖尿病患病率及相关代谢危险因素的影响。
在斯里兰卡对5000名成年人进行了一项横断面全国性调查。家族史在三个层面进行评估：（1）父母；（2）祖父母（父系和母系）；（3）兄弟姐妹。对所有患有“糖尿病”的患者进行二元逻辑回归分析，以控制混杂因素（年龄、性别、体重指数和身体活动），将“糖尿病”作为二分法因变量，并将父亲、母亲、外祖母/外祖父、祖父/祖母、兄弟姐妹和子女的家族史作为二元自变量。
样本量为4485，平均年龄为46.1±15.1岁，男性占39.5%。在所有成年人中，有家族史的患者糖尿病患病率（23.0%）显著高于无家族史者（8.2%）（P<0.001）。父母双方都有家族史时，糖尿病患病率为32.9%。家族史的存在显著增加了患糖尿病的风险[比值比（OR）：3.35，95%置信区间（CI）：2.78 - 4.03]、肥胖（OR：2.45，95%CI：1.99 - 2.99）、高血压（OR：1.25，95%CI：1.08 - 1.45）和代谢综合征（OR：2.28，95%CI：1.97 - 2.63）。在所有成年人中，父亲（OR：
