Mlodzik Marek
Mount Sinai School of Medicine, Brookdale Department of Molecular, Cell & Developmental Biology, New York, NY 10029, USA.
Trends Genet. 2002 Nov;18(11):564-71. doi: 10.1016/s0168-9525(02)02770-1.
Many types of cell show different aspects of polarization. Epithelial cells display a ubiquitous apical-basolateral polarity but often are also polarized in the plane of the epithelium - a feature referred to as 'planar cell polarity' (PCP). In Drosophila all adult epithelial cuticular structures are polarized within the plane, whereas in vertebrates examples of PCP include aspects of skin development, features of the inner ear epithelium, and the morphology and behavior of mesenchymal cells undergoing the morphogenetic movement called 'convergent extension'. Recent advances in the study of PCP establishment are beginning to unravel the molecular mechanisms that underlie this aspect of cell and tissue differentiation. Here I discuss new developments in our molecular understanding of PCP in Drosophila and compare them towhat is known about the regulation of convergent extension in vertebrates.
许多类型的细胞都表现出不同方面的极性。上皮细胞呈现出普遍存在的顶端 - 基底外侧极性，但通常在上皮平面内也呈极性分布——这一特征被称为“平面细胞极性”（PCP）。在果蝇中，所有成年上皮角质层结构在平面内都是极化的，而在脊椎动物中，PCP的例子包括皮肤发育的某些方面、内耳上皮的特征，以及经历称为“汇聚延伸”的形态发生运动的间充质细胞的形态和行为。PCP建立研究的最新进展开始揭示细胞和组织分化这一方面背后的分子机制。在这里，我将讨论我们对果蝇PCP分子理解的新进展，并将它们与脊椎动物中关于汇聚延伸调节的已知情况进行比较。
