Pope Sandra K, Shue Valorie M, Beck Cornelia
Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA.
Annu Rev Public Health. 2003;24:111-32. doi: 10.1146/annurev.publhealth.24.100901.141015. Epub 2001 Nov 6.
Alzheimer's disease (AD) appears to resemble other chronic diseases, whereby a myriad of interconnected factors, including those associated with lifestyle, are involved in disease development. In this paper, we examine accepted and proposed risk factors for AD and explore health behaviors, including diet, exercise, prevention of injury, and cognitive stimulation, that may help prevent AD. Adherence to a healthy lifestyle may directly protect against AD or may prevent diseases associated with AD, such as vascular disease and diabetes. A healthy lifestyle to prevent AD may be important throughout life rather than after disease manifestation and may be particularly relevant if other factors, such as genetic predisposition, also increase risk of AD. If changes in lifestyle can help prevent AD by reducing modifiable risk factors, this knowledge can aid individuals who wish to take action to protect themselves and their families from the disease.
阿尔茨海默病（AD）似乎与其他慢性疾病相似，即包括与生活方式相关的众多相互关联的因素都参与了疾病的发展。在本文中，我们研究了已被认可和提出的AD风险因素，并探讨了可能有助于预防AD的健康行为，包括饮食、运动、预防损伤和认知刺激。坚持健康的生活方式可能直接预防AD，或预防与AD相关的疾病，如血管疾病和糖尿病。预防AD的健康生活方式可能在一生中都很重要，而不仅仅是在疾病显现之后，如果其他因素，如遗传易感性，也增加AD风险，那么这种生活方式可能尤为重要。如果生活方式的改变可以通过减少可改变的风险因素来帮助预防AD，那么这一知识可以帮助那些希望采取行动保护自己和家人免受该疾病侵害的人。
