Coates Anthony, Hu Yanmin, Bax Richard, Page Clive
Department of Medical Microbiology, St George's Hospital Medical School, Cranmer Terrace, London SW17 ORE, UK.
Nat Rev Drug Discov. 2002 Nov;1(11):895-910. doi: 10.1038/nrd940.
The emergence of resistance to antibacterial agents is a pressing concern for human health. New drugs to combat this problem are therefore in great demand, but as past experience indicates, the time for resistance to new drugs to develop is often short. Conventionally, antibacterial drugs have been developed on the basis of their ability to inhibit bacterial multiplication, and this remains at the core of most approaches to discover new antibacterial drugs. Here, we focus primarily on an alternative novel strategy for antibacterial drug development that could potentially alleviate the current situation of drug resistance--targeting non-multiplying latent bacteria, which prolong the duration of antimicrobial chemotherapy and so might increase the rate of development of resistance.
抗菌药物耐药性的出现是人类健康面临的一个紧迫问题。因此，对抗这一问题的新药需求巨大，但正如过去的经验所示，新药产生耐药性的时间往往很短。传统上，抗菌药物是基于其抑制细菌繁殖的能力而开发的，这仍然是大多数发现新抗菌药物方法的核心。在此，我们主要关注一种用于抗菌药物开发的替代性新策略，该策略可能缓解当前的耐药状况——针对非繁殖性潜伏细菌，这会延长抗菌化疗的持续时间，从而可能降低耐药性的产生速度。
