Rosenbaum Joel L, Witman George B
Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA.
Nat Rev Mol Cell Biol. 2002 Nov;3(11):813-25. doi: 10.1038/nrm952.
Eukaryotic cilia and flagella, including primary cilia and sensory cilia, are highly conserved organelles that project from the surfaces of many cells. The assembly and maintenance of these nearly ubiquitous structures are dependent on a transport system--known as 'intraflagellar transport' (IFT)--which moves non-membrane-bound particles from the cell body out to the tip of the cilium or flagellum, and then returns them to the cell body. Recent results indicate that defects in IFT might be a primary cause of some human diseases.
真核生物的纤毛和鞭毛，包括初级纤毛和感觉纤毛，是从许多细胞表面伸出的高度保守的细胞器。这些几乎普遍存在的结构的组装和维持依赖于一种运输系统——称为“鞭毛内运输”（IFT）——它将非膜结合颗粒从细胞体运输到纤毛或鞭毛的尖端，然后再将它们运回细胞体。最近的研究结果表明，IFT缺陷可能是某些人类疾病的主要原因。
