Gavrilov N, Mermerski K, Vasilev V, Petkov P, Dimitrov K
Vet Med Nauki. 1975;12(6):62-72.
The lapinized K vaccine was used to immunize 25 five-day-old pigs and 27 ten-day-old pigs. A group of 10 pigs were also included in the experiment as controls. All animals originated from eight sows treated with a lapinized K vaccine on the 70th day of pregnancy. On the 14th day following vaccination part of the pigs of the two test groups were revaccinated. Three months later half of the immunized pigs were infected with a pathogenic swine fever virus. The remaining animals were infected then in a six months time following immunization. Systematic clinical and morphological investigations were carried out. It was concluded that the 5-day-old animals possessed much lower immunologic responsiveness to the lapinized K vaccine against swine fever as against the 10-day-old ones. Revaccination with the same vaccine on the 14th day led to a weaker immune response as compared to single vaccination. The immunity of the vaccinated 10-day-old pigs, originating from sows that had been immunized with the same vaccine during pregnancy, lasted about three months.
用兔化K疫苗对25头5日龄仔猪和27头10日龄仔猪进行免疫接种。实验还纳入一组10头猪作为对照。所有动物均来自8头在妊娠第70天用兔化K疫苗处理过的母猪。接种疫苗后第14天，对两个试验组的部分猪进行再次接种。三个月后，一半免疫猪感染致病性猪瘟病毒。其余动物在免疫接种六个月后感染。进行了系统的临床和形态学研究。得出的结论是，5日龄动物对兔化K猪瘟疫苗的免疫反应性比10日龄动物低得多。与单次接种相比，在第14天用同一疫苗再次接种导致免疫反应较弱。来自在孕期用同一疫苗免疫过的母猪的10日龄接种疫苗仔猪的免疫力持续约三个月。
