Irshad Mohammad, Peter Sudhir
Department of Laboratory Medicine, All India Institute of Medical Sciences, New Delhi.
Indian J Gastroenterol. 2002 Sep-Oct;21(5):183-4.
To investigate the prevalence of infection with hepatitis viruses in children with thalassemia receiving multiple blood transfusions.
Sera from 50 children with thalassemia aged 5-15 years (30 boys), who had each received over 80 units of blood, were evaluated for the presence of markers for hepatitis A virus (HAV; IgG and IgM anti-HAV), hepatitis B virus (HBV; HBsAg, and IgG and IgM anti-HBc), hepatitis C virus (HCV; IgG and IgM anti-HCV, and HCV RNA) and hepatitis E virus (HEV; IgG and IgM anti-HEV). IgM anti-hepatitis D virus (HDV) was looked for only in HBsAg or IgM anti-HBc positive sera.
No child had evidence of recent HAV or HDV infection. IgG anti-HAV was positive in 12 children. One patient had acute HBV infection. Nine patients were HBsAg-positive. HCV infection was present in 15 cases; six of them were HCV RNA positive, and three had superinfection with hepatitis B. Recent HEV infection was present in 5 cases.
Thalassemic patients receiving multiple blood transfusions often acquire hepatitis B (20%) and C (30%) infections. Recent hepatitis E infection was documented in 10% in this one-point study.
调查接受多次输血的地中海贫血患儿感染肝炎病毒的情况。
对50例年龄在5至15岁的地中海贫血患儿（30例男孩）的血清进行评估，这些患儿每人接受了超过80单位的血液，检测其甲型肝炎病毒（HAV；IgG和IgM抗-HAV）、乙型肝炎病毒（HBV；HBsAg以及IgG和IgM抗-HBc）、丙型肝炎病毒（HCV；IgG和IgM抗-HCV以及HCV RNA）和戊型肝炎病毒（HEV；IgG和IgM抗-HEV）标志物的存在情况。仅在HBsAg或IgM抗-HBc阳性血清中检测IgM抗丁型肝炎病毒（HDV）。
没有患儿有近期甲型肝炎或丁型肝炎感染的证据。12例患儿IgG抗-HAV呈阳性。1例患者发生急性乙型肝炎感染。9例患者HBsAg呈阳性。15例存在丙型肝炎感染；其中6例HCV RNA呈阳性，3例合并乙型肝炎重叠感染。5例存在近期戊型肝炎感染。
接受多次输血的地中海贫血患者常感染乙型肝炎（20%）和丙型肝炎（30%）。在这项单点研究中，10%的患者有近期戊型肝炎感染记录。
