Verwer R W H, Dubelaar E J G, Hermens W T J M C, Swaab D F
Graduate School Neurosciences Amsterdam, Netherlands Institute for Brain Research, Amsterdam, The Netherlands.
J Cell Mol Med. 2002 Jul-Sep;6(3):429-32. doi: 10.1111/j.1582-4934.2002.tb00522.x.
Animal models used to study human aging and neurodegeneration do not display all symptoms of these processes as they are found in humans. Recently, we have shown that many cells in neocortical slices from adult human postmortem brain may survive for extensive periods in vitro. Such cultures may enable us to study age and disease related processes directly in human brain tissue. Here, we present observations on subcortical brain tissue.
用于研究人类衰老和神经退行性变的动物模型并未表现出这些过程在人类身上所发现的所有症状。最近，我们发现来自成年人类死后大脑的新皮质切片中的许多细胞在体外可能存活很长时间。这种培养物可能使我们能够直接在人类脑组织中研究与年龄和疾病相关的过程。在这里，我们展示了对皮质下脑组织的观察结果。
