Flood D G, Coleman P D
Department of Neurology, School of Medicine and Dentistry, University of Rochester, NY 14642.
Neurobiol Aging. 1988 Sep-Dec;9(5-6):453-63. doi: 10.1016/s0197-4580(88)80098-8.
One of the several sources of interest in aging animal brains is their potential as models of the aging human brain. In this review we examine whether neuron numbers and sizes change similarly in aging human, monkey and rodent brain regions which data are available from more than one species. The number of brain regions studied in more than one species is surprisingly limited. Some regions show correspondence in age-related changes between humans and selected animal models (primary visual cortex, CA1 of hippocampus). For the majority of regions the data are conflicting, even within one species (e.g., somatosensory cortex, frontal cortex, cerebellum, cholinergic forebrain areas, locus coeruleus). Although some of the conflicting data may be attributed to procedural differences, particularly when data are expressed as density changes, much must be attributed to real species and/or strain differences in rodents. We conclude that neuron numbers and sizes may show similar age-related changes in human and animal brains only for sharply defined brain regions, animal species and/or strains, and age ranges.
对衰老动物大脑感兴趣的几个来源之一是它们作为人类衰老大脑模型的潜力。在本综述中，我们研究了在可从多个物种获得数据的人类、猴子和啮齿动物的衰老脑区中，神经元数量和大小的变化是否相似。在多个物种中研究的脑区数量惊人地有限。一些区域在人类和选定的动物模型（初级视觉皮层、海马体CA1）的年龄相关变化中显示出对应关系。对于大多数区域，数据相互矛盾，即使在一个物种内也是如此（例如，体感皮层、额叶皮层、小脑、胆碱能前脑区域、蓝斑）。尽管一些相互矛盾的数据可能归因于程序差异，特别是当数据表示为密度变化时，但许多数据必须归因于啮齿动物中实际的物种和/或品系差异。我们得出结论，仅在明确界定的脑区、动物物种和/或品系以及年龄范围内，人类和动物大脑中的神经元数量和大小可能显示出相似的年龄相关变化。
