Bailey C J, Atkins T W, Conner M J, Manley C G, Matty A J
Horm Res. 1975;6(5-6):380-6. doi: 10.1159/000178689.
Diurnal variations in food consumption and plasma concentrations of glucose and insulin were determined at 3-hourly intervals in obese hyperglycaemic mice (C57BL/6J ob/ob) and lean mice (C57BL/6J+/+). In lean mice, food consumption and plasma insulin concentrations increased during the light period and were reduced during the dark period, whereas plasma glucose concentrations were maximal at the beginning of the light period and declined to a minimum during the early dark period. In ob/ob mice, the plasma glucose concentration declined temporarily at the beginning of both the light and the dark period and became elevated towards the ends of these periods, but there were no significant diurnal variations of food consumption or plasma insulin concentrations. These observations indicate differences in the diurnal regulation of glucose homeostasis in lean and ob/ob mice.
以3小时间隔测定肥胖高血糖小鼠（C57BL/6J ob/ob）和瘦小鼠（C57BL/6J+/+）的食物消耗量以及血浆葡萄糖和胰岛素浓度的昼夜变化。在瘦小鼠中，食物消耗量和血浆胰岛素浓度在光照期增加，在黑暗期降低，而血浆葡萄糖浓度在光照期开始时最高，并在黑暗期早期降至最低。在ob/ob小鼠中，血浆葡萄糖浓度在光照期和黑暗期开始时暂时下降，并在这些时期结束时升高，但食物消耗量或血浆胰岛素浓度没有明显的昼夜变化。这些观察结果表明瘦小鼠和ob/ob小鼠在葡萄糖稳态的昼夜调节方面存在差异。
