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Pancreatic polypeptide: a possible role in the regulation of food intake in the mouse. Hypothesis.

作者信息

Malaisse-Lagae F, Carpentier J L, Patel Y C, Malaisse W J, Orci L

出版信息

Experientia. 1977 Jul 15;33(7):915-7. doi: 10.1007/BF01951279.

DOI:10.1007/BF01951279
PMID:891771
Abstract

Pancreatic polypeptide (PP) is a recently identified hormone produced by pancreatic endocrine cells. The islets of genetically obese mice (ob/ob, C57 BL/6J), which are suspected to lack a circulating satiety factor, contain relatively few of the PP-producing cells. Administration of bovine pancreatic polypeptide (bPP) reduces food intake and suppresses body weight gain in the hyperphagic obese mice. It is postulated that PP participates in the regulation of food intake in a manner as yet undefined.

摘要

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本文引用的文献

1
Isolation and characterization of chicken insulin.鸡胰岛素的分离与特性鉴定
Endocrinology. 1968 Dec;83(6):1323-30. doi: 10.1210/endo-83-6-1323.
2
Effects of parabiosis of obese with diabetes and normal mice.肥胖小鼠与糖尿病小鼠及正常小鼠联体共生的效应。
Diabetologia. 1973 Aug;9(4):294-8. doi: 10.1007/BF01221857.
3
Localization of APP, a postulated new hormone, to a pancreatic endocrine cell type.假定的新激素APP在胰腺一种内分泌细胞类型中的定位。
J Clin Med. 2014 Jul 15;3(3):763-94. doi: 10.3390/jcm3030763.
4
A Historical Perspective on the Identification of Cell Types in Pancreatic Islets of Langerhans by Staining and Histochemical Techniques.通过染色和组织化学技术鉴定胰岛细胞类型的历史视角
J Histochem Cytochem. 2015 Aug;63(8):543-58. doi: 10.1369/0022155415589119.
5
The role of gastrointestinal hormones in the pathogenesis of obesity and type 2 diabetes.胃肠激素在肥胖症和2型糖尿病发病机制中的作用。
Prz Gastroenterol. 2014;9(2):69-76. doi: 10.5114/pg.2014.42498. Epub 2014 May 5.
6
New advances in models and strategies for developing anti-obesity drugs.新型肥胖症治疗药物模型和策略的新进展。
Expert Opin Drug Discov. 2013 Jun;8(6):655-71. doi: 10.1517/17460441.2013.792804. Epub 2013 Apr 29.
7
Appetite regulation and weight control: the role of gut hormones.食欲调节和体重控制：肠道激素的作用。
Nutr Diabetes. 2012 Jan 16;2(1):e26. doi: 10.1038/nutd.2011.21.
8
Obesity pharmacotherapy: what is next?肥胖症药物治疗：下一步是什么？
Mol Aspects Med. 2013 Feb;34(1):71-83. doi: 10.1016/j.mam.2012.10.005. Epub 2012 Oct 24.
9
Gut hormones: the future of obesity treatment?肠道激素：肥胖治疗的未来？
Br J Clin Pharmacol. 2012 Dec;74(6):911-9. doi: 10.1111/j.1365-2125.2012.04278.x.
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Expert Rev Clin Pharmacol. 2011 Mar;4(2):243-59. doi: 10.1586/ecp.11.3.
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4
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Gastroenterology. 1974 Oct;67(4):737-8.
5
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Studies of the distribution of a new avian pancreatic polypeptide and insulin among birds, reptiles, amphibians and mammals.一种新型禽胰多肽和胰岛素在鸟类、爬行动物、两栖动物及哺乳动物中的分布研究。
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Diurnal variations of food consumption, plasma glucose and plasma insulin concentrations in lean and obese hyperglycaemic mice.瘦型和肥胖型高血糖小鼠的食物摄入量、血浆葡萄糖和血浆胰岛素浓度的昼夜变化
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