Hewitt Michael C, Snyder Daniel A, Seeberger Peter H
Department of Chemistry, Massachusetts Institute of Technology, Cambridge 02139, USA.
J Am Chem Soc. 2002 Nov 13;124(45):13434-6. doi: 10.1021/ja027538k.
Described is an automated synthesis of hexasaccharide malarial toxin 1, currently under development as a malaria vaccine candidate. Using a combination of automated solid-phase methods and solution-phase fragment coupling, the target glycosylphosphatidylinositol was assembled in a matter of days, compared with several weeks for a comparable solution-phase synthesis.
本文描述了一种六糖疟疾毒素1的自动化合成方法，该毒素目前正作为疟疾疫苗候选物进行研发。通过结合自动化固相方法和溶液相片段偶联，目标糖基磷脂酰肌醇在数天内即可组装完成，而类似的溶液相合成则需要数周时间。
