糖疗法：新进展激发了聚糖在医学领域的再度兴起。
Glycotherapy: new advances inspire a reemergence of glycans in medicine.
作者信息
Hudak Jason E, Bertozzi Carolyn R
机构信息
Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA.
Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA.
出版信息
Chem Biol. 2014 Jan 16;21(1):16-37. doi: 10.1016/j.chembiol.2013.09.010. Epub 2013 Nov 21.
The beginning of the 20(th) century marked the dawn of modern medicine with glycan-based therapies at the forefront. However, glycans quickly became overshadowed as DNA- and protein-focused treatments became readily accessible. The recent development of new tools and techniques to study and produce structurally defined carbohydrates has spurred renewed interest in the therapeutic applications of glycans. This review focuses on advances within the past decade that are bringing glycan-based treatments back to the forefront of medicine and the technologies that are driving these efforts. These include the use of glycans themselves as therapeutic molecules as well as engineering protein and cell surface glycans to suit clinical applications. Glycan therapeutics offer a rich and promising frontier for developments in the academic, biopharmaceutical, and medical fields.
20世纪初标志着现代医学的开端，基于聚糖的疗法处于前沿。然而，随着以DNA和蛋白质为重点的治疗方法变得容易获得，聚糖很快就黯然失色。最近用于研究和生产结构明确的碳水化合物的新工具和技术的发展，激发了人们对聚糖治疗应用的新兴趣。本综述重点关注过去十年中使基于聚糖的治疗方法重新回到医学前沿的进展以及推动这些努力的技术。这些包括将聚糖本身用作治疗分子，以及对蛋白质和细胞表面聚糖进行工程改造以适应临床应用。聚糖疗法为学术、生物制药和医学领域的发展提供了一个丰富且前景广阔的前沿领域。
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