口腔癌发生过程中细胞角蛋白19的变化。
The changes of cytokeratin 19 during oral carcinogenesis.
作者信息
Nie Minhai, Zhong Li, Zeng Guangming, Li Bingqi
机构信息
Department of Oral Medicine, Hospital Affiliated to Luzhou Medical College, Luzhou Sichuan 646000, China.
出版信息
Zhonghua Kou Qiang Yi Xue Za Zhi. 2002 May;37(3):187-90.
OBJECTIVE
To investigate the changes of cytokeratin 19 during oral carcinogenesis.
METHODS
53 specimens including normal oral mucosa, oral epithelial hyperplasia, oral epithelial dysplasia and oral squamous cell carcinoma were investigated by immunohistochemistry, SDS-PAGE and Western blotting.
RESULTS
CK19 was detectable in suprabasal cell layers in epithelial dysplasia and in oral cancer, especially in poor-differentiated cancerous cells. With the lesions getting worse, the positive rate, the intensity and the constituent ratio of CK19 raised significantly.
CONCLUSIONS
The results suggest that the CK19 expression in suprabasal cell layers of oral mucosa can be used as a marker of diagnosis of oral precancerous lesions and CK19 expression is the initial events during oral carcinogenesis.
目的
研究细胞角蛋白19在口腔癌发生过程中的变化。
方法
采用免疫组织化学、SDS - PAGE和蛋白质免疫印迹法对53例标本进行研究，这些标本包括正常口腔黏膜、口腔上皮增生、口腔上皮发育异常及口腔鳞状细胞癌。
结果
细胞角蛋白19在上皮发育异常及口腔癌的基底层以上细胞层中可检测到，尤其在低分化癌细胞中。随着病变加重，细胞角蛋白19的阳性率、强度及构成比显著升高。
结论
结果表明，口腔黏膜基底层以上细胞层中细胞角蛋白19的表达可作为口腔癌前病变诊断的标志物，且细胞角蛋白19的表达是口腔癌发生过程中的起始事件。
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