Karnati Vishnu Vardhan, Gao Xingming, Gao Shouhai, Yang Wenqian, Ni Weijuan, Sankar Sabapathy, Wang Binghe
Department of Chemistry, North Carolina State University, Raleigh, NC 27695-8204, USA.
Bioorg Med Chem Lett. 2002 Dec 2;12(23):3373-7. doi: 10.1016/s0960-894x(02)00767-9.
A glucose selective diphenylboronic acid fluorescent sensor (10a) with a K(a) of 1472M(-1) has been synthesized and evaluated. This sensor shows a 43- and 49-fold selectivity for glucose over fructose and galactose, respectively. The binding affinity improvement is about 300-fold and the selectivity improvement for glucose over fructose is about 1400-fold compared with the monoboronic acid compound, phenylboronic acid. 1H NMR studies indicate that sensor 10a binds with alpha-D-glucofuranose in a bidentate manner (1:1 ratio).
已合成并评估了一种葡萄糖选择性二苯基硼酸荧光传感器（10a），其K(a)为1472M(-1)。该传感器对葡萄糖的选择性分别比对果糖和半乳糖高43倍和49倍。与单硼酸化合物苯硼酸相比，其结合亲和力提高了约300倍，对葡萄糖相对于果糖的选择性提高了约1400倍。1H NMR研究表明，传感器10a以双齿方式（1:1比例）与α-D-呋喃葡萄糖结合。
