Department of Chemistry, Iowa State University , Ames, Iowa 50011-3111, United States.
J Am Chem Soc. 2016 Aug 10;138(31):9759-62. doi: 10.1021/jacs.6b04613. Epub 2016 Jul 27.
Molecular imprinting within cross-linked micelles using 4-vinylphenylboronate derivatives of carbohydrates provided water-soluble nanoparticle receptors selective for the carbohydrate templates. Complete differentiation of d-aldohexoses could be achieved by these receptors if a single inversion of hydroxyl occurred at C2 or C4 of the sugar or if two or more inversions took place. Glycosides with a hydrophobic aglycan displayed stronger binding due to increased hydrophobic interactions.
利用碳水化合物的 4-乙烯基苯硼酸衍生物在交联胶束内进行分子印迹，为碳水化合物模板提供了对水可溶性纳米颗粒受体的选择性。如果糖的 C2 或 C4 位发生单个羟基反转，或者发生两个或更多反转，则这些受体可以实现 d-醛糖的完全区分。由于疏水性糖苷配基增加了疏水性相互作用，因此具有疏水性糖苷配基的糖苷显示出更强的结合能力。
