Kim Young-Suk, Jung Eun-Ah, Shin Ji-Eun, Chang Jong-Chul, Yang Hyung-Kil, Kim Nam-Jae, Cho Ki-Ho, Bae Hyung-Sup, Moon Sang-Kwan, Kim Dong-Hyun
College of Oriental Medicine, Kyung Hee University, Seoul, Korea.
Biol Pharm Bull. 2002 Nov;25(11):1442-5. doi: 10.1248/bpb.25.1442.
To evaluate the antihyperlipidemic activities of Orengedokuto (OT) and Daio-Orengedokuto (DOT), the inhibitory effects of these polyprescriptions on HMG-CoA reductase and pancreatic lipase and on the rat hyperlipidemic model induced by Triton WR-1339 were measured. OT potently inhibited HMG-CoA reductase but did not inhibit lipase. Among their ingredients, Coptidis Rhizoma was the most potent inhibitor, followed by Rhei Rhizoma. The HMG-CoA reductase-inhibitory activity of 80% EtOH extract was superior to that of water extract. However, DOT potently inhibited HMG CoA-reductase as well as pancreatic lipase. In the rat hyperlipidemic model induced by Triton WR-1339, OT and DOT decreased serum total cholesterol and low-density lipoprotein cholesterol levels. DOT also decreased serum triglyceride levels, but OT did not decrease it. These results suggest that the antihyperlipidemic activity of DOT may originate from the inhibition of pancreatic lipase as well as HMG-CoA reductase.
为评估黄连解毒汤（OT）和大黄黄连解毒汤（DOT）的降血脂活性，测定了这些复方制剂对HMG-CoA还原酶和胰脂肪酶的抑制作用以及对Triton WR-1339诱导的大鼠高脂血症模型的影响。OT能有效抑制HMG-CoA还原酶，但不抑制脂肪酶。在其成分中，黄连是最有效的抑制剂，其次是大黄。80%乙醇提取物的HMG-CoA还原酶抑制活性优于水提取物。然而，DOT能有效抑制HMG-CoA还原酶以及胰脂肪酶。在Triton WR-1339诱导的大鼠高脂血症模型中，OT和DOT降低了血清总胆固醇和低密度脂蛋白胆固醇水平。DOT还降低了血清甘油三酯水平，但OT没有降低。这些结果表明，DOT的降血脂活性可能源于对胰脂肪酶以及HMG-CoA还原酶的抑制。
