Zavala Walther D, De Simone Dino Sanchez, Sacerdote Fabio L, Cavicchia Juan C
Instituto de Histología y Embriología, Cuyo Medical School, Mendoza, Argentina.
Anat Rec. 2002 Dec 1;268(4):360-4. doi: 10.1002/ar.10147.
Langerhans cells (LCs) are dendritic components of stratified epithelia, presenting antigens to other cells of the immune system that play a crucial role in local defense. The paucity of information about their significance in the esophageal mucosa was addressed by studying their distribution and morphology in this particular location. LCs were identified by immunohistochemical detection of CD1a, a cell-specific marker, using a monoclonal antibody, as well as by electron microscopic identification of characteristic Birbeck granules, among other typical morphological features. Cell counts carried out at 25 and 35 cm distal to the dental arch demonstrated significant differences in number and size between the two locations. The upper region contained 10.4 +/- 0.8 cells (mean +/- SEM) vs. 18.4 +/- 1.4 cells in the lower region. Also, cells in the lower region were larger and appeared to have longer dendritic processes. To our knowledge this is the first report of regional differences in number and morphology of LCs in human esophageal mucosa.
朗格汉斯细胞（LCs）是复层上皮的树突状成分，可将抗原呈递给免疫系统的其他细胞，在局部防御中起关键作用。通过研究它们在这个特定部位的分布和形态，解决了关于它们在食管黏膜中意义的信息匮乏问题。通过使用单克隆抗体免疫组织化学检测细胞特异性标志物CD1a来鉴定LCs，以及通过电子显微镜鉴定特征性的伯贝克颗粒和其他典型形态特征来进行鉴定。在牙弓远端25厘米和35厘米处进行的细胞计数显示，两个部位在数量和大小上存在显著差异。上部区域含有10.4±0.8个细胞（平均值±标准误），而下部区域为18.4±1.4个细胞。此外，下部区域的细胞更大，且似乎具有更长的树突状突起。据我们所知，这是关于人类食管黏膜中LCs数量和形态区域差异的首次报告。
