Feng Jin-Yun, Peng Zhen-Hui, Tang Xiao-Ping, Geng Song-Mei, Liu Yu-Ping
Department of Dermatology, The Second Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
J Cutan Pathol. 2008 Jan;35(1):15-20. doi: 10.1111/j.1600-0560.2007.00763.x.
There are few studies on the abnormal morphology of Langerhans cells (LCs) in condyloma acuminatum (CA) lesions and the essence of the abnormal morphology of LCs in CA lesions is still not well elucidated. The aim of this study was to further investigate the morphological features of LCs in CA lesions.
CD1a(+) LCs in 13 CA lesions and in 13 normal controls were labeled using immunohistochemistry and examined by light microscopy. Ultrastructural investigation on LCs in six CA lesions and in six normal controls was performed by electron microscopy.
Compared with those in normal controls, most CD1a(+) LCs in CA lesions exhibited dysplastic dendrities and abnormal distribution. The number of CD1a(+) LCs in CA lesions (26.31 +/- 18.84) was statistically lower (p < 0.001) than that in normal controls (72.00 +/- 27.40). Electron microscopy showed that the number of Birbeck granules within lesional LCs (4.00 +/- 2.94) was significantly decreased (p < 0.001) than that within normal LCs (10.80 +/- 4.78). The ultrastructures of most lesional LCs displayed degenerative changes.
The morphology of most LCs in CA lesions shows degenerative changes, which suggest that these LCs have been functionally impaired.
关于尖锐湿疣（CA）病变中朗格汉斯细胞（LCs）形态异常的研究较少，且CA病变中LCs形态异常的本质仍未得到充分阐明。本研究旨在进一步探究CA病变中LCs的形态特征。
采用免疫组织化学方法标记13例CA病变和13例正常对照中的CD1a(+) LCs，并通过光学显微镜进行观察。对6例CA病变和6例正常对照中的LCs进行电子显微镜超微结构研究。
与正常对照相比，CA病变中的大多数CD1a(+) LCs表现出树突发育异常和分布异常。CA病变中CD1a(+) LCs的数量（26.31±18.84）在统计学上低于正常对照（72.00±27.40）（p<0.001）。电子显微镜显示，病变LCs内的伯贝克颗粒数量（4.00±2.94）明显低于正常LCs内的数量（10.80±4.78）（p<0.001）。大多数病变LCs的超微结构显示出退行性变化。
CA病变中大多数LCs的形态显示出退行性变化，这表明这些LCs的功能已受损。
