Kapoor Seema, Ratan Simmi K, Kashyap Ravi, Mittal S K, Rajeshwari K, Rawat H, Verma Jyoti
Department of Pediatrics, MAMC and allied LN Hospital, New Delhi.
Indian J Pediatr. 2002 Sep;69(9):761-4. doi: 10.1007/BF02723686.
To evaluate protien using enteropathy by Tc-99m dextran scintigraphy.
Methods for detecting protein loss from the intestine revolve around fecal nitrogen excretion, the clearance of alpha-1 antitrypsin in stools and by endoscopic biopsy.
The diagnosis of protein-losing enteropathy (PLE) can also be established by a scintigraphic method that is noninvasive, simple and requires no patient preparation or motivation. This diagnostic modality can also delineate the site of protein loss, thereby offering a targeted approach, and if need be, surgery. Radiolabelling of a non-protein, noncolloidal, nonparticulate and biofriendly molecule like dextran with Technetium-99m for imaging enteric protein loss was utilized in imaging eight children with PLE.
The results were encouraging. The authors advocate the use of this diagnostic tool in identifying patients with PLE, particularly in the pediatric age group.
通过锝-99m右旋糖酐闪烁扫描术评估蛋白丢失性肠病。
检测肠道蛋白丢失的方法围绕粪便氮排泄、粪便中α-1抗胰蛋白酶清除率以及内镜活检展开。
蛋白丢失性肠病（PLE）的诊断也可通过一种非侵入性、简单且无需患者准备或配合的闪烁扫描方法来确立。这种诊断方式还能确定蛋白丢失部位，从而提供有针对性的方法，必要时可进行手术。用锝-99m对右旋糖酐这种非蛋白质、非胶体、非颗粒且生物相容性良好的分子进行放射性标记以成像肠道蛋白丢失，用于对8例PLE患儿进行成像。
结果令人鼓舞。作者主张使用这种诊断工具来识别PLE患者，尤其是儿童年龄组的患者。
