Sugimoto Masahiko, Sugimoto Mitsuru, Uji Yukitaka
Department of Ophthalmology, Mie University School of Medicine, Tsu-city, Japan.
Can J Ophthalmol. 2002 Oct;37(6):342-5. doi: 10.1016/s0008-4182(02)80004-7.
There have been several reports, mostly qualitative, of ocular side effects of latanoprost, including lengthening of eyelashes. We investigated changes in eyelash length in patients receiving topically administered latanoprost.
Seventeen patients (11 men and 6 women aged 63 to 80 years) with glaucoma or ocular hypertension were treated with latanoprost (one drop to one eye daily at bedtime). All had dark brown irises. At the start of treatment and after 2, 6 and 10 weeks of treatment, a single eyelash was removed from the centre of the upper eyelid of the treated and fellow (control) eyes and measured. Adverse events (defined as any undesirable event occurring in a subject, regardless of whether it was considered related to the latanoprost treatment) were monitored carefully. At each examination patients were asked whether they had any ocular or systemic symptoms.
For the eyes treated with latanoprost, the mean eyelash length (and standard deviation) was 5.8 mm (0.7 mm) at baseline, 6.5 mm (0.6 mm) at 2 weeks, 6.5 mm (0.9 mm) at 6 weeks and 6.6 mm (0.7 mm) at 10 weeks (p < 0.001 for all differences from baseline). The corresponding values for the untreated eyes were 5.7 mm (0.7 mm), 5.8 mm (0.7 mm), 5.9 mm (0.7 mm) and 5.6 mm (0.7 mm); all differences were nonsignificant.
Latanoprost significantly increases eyelash length.
已有多篇关于拉坦前列素眼部副作用的报道，大多为定性研究，其中包括睫毛变长。我们研究了局部应用拉坦前列素患者的睫毛长度变化。
17例（11例男性和6例女性，年龄63至80岁）青光眼或高眼压症患者接受拉坦前列素治疗（每晚每眼一滴）。所有患者虹膜均为深褐色。在治疗开始时以及治疗2周、6周和10周后，从治疗眼和对侧（对照）眼上睑中央拔除一根睫毛并测量。仔细监测不良事件（定义为受试者发生的任何不良事件，无论是否被认为与拉坦前列素治疗有关）。每次检查时询问患者是否有任何眼部或全身症状。
接受拉坦前列素治疗的眼睛，基线时睫毛平均长度（及标准差）为5.8毫米（0.7毫米），2周时为6.5毫米（0.6毫米），6周时为6.5毫米（0.9毫米），10周时为6.6毫米（0.7毫米）（与基线相比所有差异p<0.001）。未治疗眼的相应值分别为5.7毫米（0.7毫米）、5.8毫米（0.7毫米）、5.9毫米（0.7毫米）和5.6毫米（0.7毫米）；所有差异均无统计学意义。
拉坦前列素可显著增加睫毛长度。
