氨基和胍基-G-钳位肽核酸单体的合成。
Synthesis of amino- and guanidino-G-clamp PNA monomers.
作者信息
Ausín Cristina, Ortega José-Antonio, Robles Jordi, Grandas Anna, Pedroso Enrique
机构信息
Departament de Química Orgànica, Facultat de Química, Universitat de Barcelona, Martí i Franquès 1, 08028 Barcelona, Spain.
出版信息
Org Lett. 2002 Nov 14;4(23):4073-5. doi: 10.1021/ol026815p.
PMID:12423089
Abstract
Syntheses of the protected amino- and guanidino-G-clamp PNA monomers, 9a and 9b, respectively, have been accomplished in eight steps from 5-bromouracil. Enhanced stacking interactions and additional hydrogen bonds with guanine should increase the affinity of PNAs incorporating these cytosine analogues for their complementary strands. [reaction: see text]
摘要
分别从5-溴尿嘧啶出发，通过八步反应完成了受保护的氨基-和胍基-G-钳PNA单体（分别为9a和9b）的合成。与鸟嘌呤增强的堆积相互作用和额外的氢键应会增加掺入这些胞嘧啶类似物的PNA与其互补链的亲和力。[反应：见正文]
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