D'Costa M, Kumar V A, Ganesh K N
Division of Organic Chemistry (Synthesis), National Chemical Laboratory, Pune, India.
Org Lett. 1999 Nov 18;1(10):1513-6. doi: 10.1021/ol990835i.
[formula: see text] The replacement of the glycyl component in the peptide nucleic acid (PNA) backbone by a prolyl unit bearing a nucleobase leads to the aminoethylprolyl (aep) PNAs, which are chiral and cationic. The homooligomeric aepPNA binds to complementary DNA sequences with high affinity and sequence specificity, forming highly stable triplexes.
[化学式：见正文] 在肽核酸（PNA）主链中，用带有核碱基的脯氨酰单元取代甘氨酰成分，可得到氨基乙基脯氨酰（aep）PNA，其具有手性且带正电荷。同聚寡聚aepPNA以高亲和力和序列特异性与互补DNA序列结合，形成高度稳定的三链体。
