Brodsky J B, Burgess G E
JAMA. 1975 Dec 15;234(11):1156-7.
A patient with factor XI deficiency had pulmonary embolism, although his factor XI assay was less than 1% of normal and his postoperative course was complicated by prolonged bleeding. Programs designed to prevent postoperative venous thrombosis should be carried out in factor XI-deficient patients, since the deficient state offers no protection from a pulmonary embolus. All surgical patients who are to receive low-dose heparin therapy as a part of such a program should be screened by means of preoperative determination of the partial thromboplastin time, to identify previously unsuspected bleeding disorders.
一名患有因子XI缺乏症的患者发生了肺栓塞，尽管其因子XI检测值低于正常水平的1%，且术后病程因出血时间延长而复杂化。对于因子XI缺乏的患者，应实施旨在预防术后静脉血栓形成的方案，因为这种缺乏状态并不能预防肺栓塞。作为该方案一部分而接受低剂量肝素治疗的所有外科患者，都应通过术前测定部分凝血活酶时间进行筛查，以识别先前未被怀疑的出血性疾病。
