Kaufman J M
J Urol. 1977 Jan;117(1):75-8. doi: 10.1016/s0022-5347(17)58343-3.
Factor XI deficiency, an uncommon inherited coagulopathy characterized by an absence of bleeding history but bleeding after an operation or trauma, has not been reported previously in urologic patients. The diagnosis is made by a specific factor assay after an abnormal partial thromboplastin time and the treatment is fresh frozen plasma. Four patients with factor XI deficiency underwent open prostatectomy and all experienced excessive postoperative bleeding and prolonged hospitalization. Treatment with fresh frozen plasma controlled bleeding in 3 patients, 1 of whom suffered congestive heart failure from the fluid load imposed. The fourth patient bled heavily despite fresh frozen plasma and required several additional procedures and 29 units of blood and packed cells.
因子 XI 缺乏症是一种罕见的遗传性凝血障碍，其特征是无出血史，但在手术或创伤后出血，此前尚未在泌尿外科患者中报道过。诊断通过在活化部分凝血活酶时间异常后进行特定因子检测来做出，治疗方法是输注新鲜冰冻血浆。四名患有因子 XI 缺乏症的患者接受了开放性前列腺切除术，均出现术后出血过多和住院时间延长的情况。三名患者通过输注新鲜冰冻血浆控制了出血，其中一名患者因液体负荷过重而出现充血性心力衰竭。第四名患者尽管输注了新鲜冰冻血浆仍大量出血，需要进行多次额外手术，并输注了29单位的血液和红细胞悬液。
