Söylev Meltem F, Koçak Nilüfer, Kuvaki Bahar, Ozkan Seyhan B, Kir Erkin
School of Medicine, Dokuz Eylül University, TR-35320 Narlidere-Izmir, Turkey.
Ophthalmologica. 2002 Sep-Oct;216(5):355-8. doi: 10.1159/000066186.
We investigated the efficacy of an eutectic mixture of local anesthetics (EMLA) in reducing the pain of a botulinum toxin injection into eyelids. 17 patients with facial dyskinesia (9 blepharospasm and 8 hemifacial spasm) who had been treated regularly with botulinum toxin injections received EMLA cream and placebo. The pain was assessed by the ophthalmologist and the patient. Injection with EMLA cream showed lower pain scores (mean 1.82 +/- 2.13, median 1) than injection with placebo (8.76 +/- 2.17; p = 0.0001). Percutaneous anesthesia induced by EMLA cream is an effective and safe method which improves the comfort in patients who need repeated botulinum toxin injections for their facial dyskinesia.
我们研究了局部麻醉剂的共熔混合物（EMLA）在减轻肉毒杆菌毒素注射到眼睑时疼痛方面的疗效。17例面部运动障碍患者（9例眼睑痉挛和8例半面痉挛），他们一直定期接受肉毒杆菌毒素注射，分别接受了EMLA乳膏和安慰剂治疗。疼痛由眼科医生和患者进行评估。与注射安慰剂（8.76±2.17；p = 0.0001）相比，注射EMLA乳膏的疼痛评分更低（平均1.82±2.13，中位数1）。EMLA乳膏诱导的经皮麻醉是一种有效且安全的方法，可提高因面部运动障碍需要反复注射肉毒杆菌毒素的患者的舒适度。
