de la Torre Juan Carlos
Department of Neuropharmacology, Division of Virology, IMM-6, Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA 92037, USA.
J Infect Dis. 2002 Dec 1;186 Suppl 2:S241-7. doi: 10.1086/344936.
Borna disease virus (BDV) causes central nervous system (CNS) disease that is frequently manifested by behavioral abnormalities. BDV is a nonsegmented, negative, single-stranded RNA virus. On the basis of its unique genetic and biologic features, BDV is the prototypic member of a new virus family, Bornaviridae, within the order Mononegavirales. Therefore, the investigation of the molecular and cell biology of BDV may provide new insights about virus-cell interactions in the CNS. BDV is an important model system for the investigation of viral persistence in the CNS. Serologic and molecular epidemiologic studies suggest that BDV can infect humans. Despite controversy about potential association with human neuropsychiatric illnesses, BDV affords an intriguing model for the study of these illnesses. Neonatal BDV-infected rats display neurodevelopmental, physiologic, and neurobehavioral abnormalities that closely parallel some of the main features associated with several human mental disorders.
博尔纳病病毒（BDV）可引发中枢神经系统（CNS）疾病，其症状常表现为行为异常。BDV是一种不分节段的、负链单链RNA病毒。基于其独特的遗传和生物学特性，BDV是单股负链RNA病毒目（Mononegavirales）中一个新病毒科——博尔纳病毒科（Bornaviridae）的原型成员。因此，对BDV分子和细胞生物学的研究可能为中枢神经系统中病毒与细胞的相互作用提供新的见解。BDV是研究病毒在中枢神经系统中持续性感染的重要模型系统。血清学和分子流行病学研究表明，BDV可感染人类。尽管关于BDV与人类神经精神疾病潜在关联存在争议，但BDV为研究这些疾病提供了一个有趣的模型。新生期感染BDV的大鼠表现出神经发育、生理和神经行为异常，这些异常与几种人类精神障碍的一些主要特征极为相似。
