啮齿动物中的博尔纳病毒免疫发病机制：人类神经疾病的模型

Bornavirus immunopathogenesis in rodents: models for human neurological diseases.

作者信息

Briese T, Hornig M, Lipkin W I

机构信息

Laboratory for the Study of Emerging Diseases, Department of Neurology, 3101 Gillespie Neuroscience Research Facility, University of California, Irvine, California, CA 92697-4292, USA.

出版信息

J Neurovirol. 1999 Dec;5(6):604-12. doi: 10.3109/13550289909021289.

DOI:10.3109/13550289909021289

PMID:10602401

Abstract

Although the question of human BDV infection remains to be resolved, burgeoning interest in this unique pathogen has provided tools for exploring the pharmacology and neurochemistry of neuropsychiatric disorders potentially linked to BDV infection. Two animal models have been established based on BDV infection of adult or neonatal Lewis rats. Analysis of these models is already yielding insights into mechanisms by which neurotropic agents and/or immune factors may impact developing or mature CNS circuitry to effect complex disturbances in movement and behavior.

摘要

尽管人类是否感染BDV的问题仍有待解决，但对这种独特病原体日益增长的兴趣为探索可能与BDV感染相关的神经精神疾病的药理学和神经化学提供了工具。基于成年或新生Lewis大鼠的BDV感染，已经建立了两种动物模型。对这些模型的分析已经为亲神经因子和/或免疫因子可能影响发育中的或成熟的中枢神经系统回路以导致运动和行为复杂紊乱的机制提供了见解。