Langeland N, Teig V
Acta Endocrinol (Copenh). 1975 Dec;80(4):784-94. doi: 10.1530/acta.0.0800784.
In vitro collagen metabolism in metaphyseal bone has been studied during the first few hours and days after the start of in vivo treatment of castrated female rats with various doses of oestradiol-17 beta. Already during the first 2 h after the start of treatment with oestradiol-17 beta 2 mug/day and within the first 24 h in the rats receiving 20 mug/day, a reduction of the collagen incorporation rate was demonstreated. The incorporation rates remained at approximately the same reduced level during the following 3 weeks. In rats receiving oestradiol-17 beta 1 mug/day no such reduced incorporation rate could be demonstrated during the first 36 h after the start of treatment. The bone collagen resorption rate was significantly elevated during the first 3 days of treatment in the animals receiving oestradiol-17 beta both 1 and 20 mug/day. After this time the resorption rates gradually fell to levels significantly below controls at 3 weeks after start of treatment.
在给去势雌性大鼠用不同剂量的17β-雌二醇进行体内治疗后的最初几小时和几天内，对干骺端骨的体外胶原代谢进行了研究。在用17β-雌二醇2微克/天治疗开始后的最初2小时内，以及在接受20微克/天的大鼠的最初24小时内，胶原掺入率均出现降低。在接下来的3周内，掺入率维持在大致相同的降低水平。在用17β-雌二醇1微克/天治疗的大鼠中，在治疗开始后的最初36小时内未观察到这种掺入率降低的情况。在接受1微克/天和20微克/天17β-雌二醇治疗的动物中，治疗的前3天骨胶原吸收率显著升高。在此之后，吸收率逐渐下降，在治疗开始3周时显著低于对照组水平。
