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银杏叶提取物对声音损伤的影响(作者译)

[The influence on sound damages by an extract of ginkgo biloba (author's transl)].

作者信息

Stange G, Benning C D

出版信息

Arch Otorhinolaryngol. 1975 Jul 8;209(3):203-15. doi: 10.1007/BF00453774.

Abstract

A fraction of Ginkgo biloba, used in experiments with animals ensured significantly the diminution of sound damages caused by white noise or by a pure tone of 4.5 kHz. Higher amplitudes of the acoustic nerve potentials show the protective effect of this fraction of Ginkgo biloba at acute sound damages. It is moreover possible to hold physiologically the adaptation of excitation of the hair cells of the organ of Corti by the fraction of Ginkgo biloba before and after sound damage caused by white noise or during a pure tone of 4.5 kHz. The influence of the fraction of Ginkgo biloba can be seen by a significantly slower recovery of the noise damaged evoked potentials of the acoustic cortex. An efferent protective influence on the neurons of the acoustic cortex is discussed. The fraction of Ginkgo biloba in this form of solution has not been tested for clinical use but it seems to be rich in meaning.

摘要

在动物实验中使用的一部分银杏叶提取物确实显著减少了由白噪声或4.5千赫纯音引起的听力损伤。听神经电位的较高振幅显示了这种银杏叶提取物在急性听力损伤时的保护作用。此外,在白噪声或4.5千赫纯音引起的听力损伤之前和之后,或在4.5千赫纯音期间,银杏叶提取物有可能在生理上维持柯蒂氏器毛细胞兴奋的适应性。通过听觉皮层噪声损伤诱发电位的显著较慢恢复可以看出银杏叶提取物的影响。讨论了对听觉皮层神经元的传出保护作用。这种溶液形式的银杏叶提取物尚未进行临床应用测试,但似乎具有重要意义。

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