银杏叶提取物对庆大霉素局部给药诱导豚鼠耳蜗损伤的影响。
Effects of Ginkgo biloba extract on the cochlear damage induced by local gentamicin installation in guinea pigs.
作者信息
Jung H W, Chang S O, Kim C S, Rhee C S, Lim D H
机构信息
Department of Otorhinolaryngology - Head & Neck Surgery, Seoul National University College of Medicine, Korea.
出版信息
J Korean Med Sci. 1998 Oct;13(5):525-8. doi: 10.3346/jkms.1998.13.5.525.
Investigations evaluating the protective effect of Ginkgo biloba extract (EGb) on gentamicin (GM) ototoxicity were undertaken. Guinea pigs treated with 5 mg/kg gentamicin sulfate on the round window niche (RWN) showed acute changes on electrocochleogram and hair cell or microvilli damage on scanning electron microscopy (SEM). There was accumulation of GM in the whole cochlea, especially in the organ of Corti, stria vascularis, and type III fibrocyte on immunohistochemical study. However, the guinea pigs pretreated with local or systemic EGb revealed no significant changes by local GM installation. From these results, we concluded that EGb has a protective effect on the development of GM ototoxicity in the cochlea.
开展了评估银杏叶提取物（EGb）对庆大霉素（GM）耳毒性保护作用的研究。在圆窗龛（RWN）处用5mg/kg硫酸庆大霉素处理的豚鼠，在耳蜗电图上显示出急性变化，并且在扫描电子显微镜（SEM）下可见毛细胞或微绒毛损伤。免疫组织化学研究表明，GM在整个耳蜗中蓄积，尤其是在柯蒂氏器、血管纹和III型纤维细胞中。然而，经局部或全身EGb预处理的豚鼠，通过局部安装GM未显示出明显变化。从这些结果来看，我们得出结论，EGb对耳蜗中GM耳毒性的发生具有保护作用。
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