• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

[用于测试抗精神药物的动物实验中的物理因素]

[Physical factors in animal experiments for testing antimasspsychotic drugs].

作者信息

Asteridis H, Beckmann P, Diotinsky I

出版信息

Arzneimittelforschung. 1975 Sep;25(9):1463-5.

PMID:1242672
Abstract

Lemmingson et al. have observed that the movement of masspsychotic lemmings (Lemmus lemmus) shows a distinct preference for the left direction. They suggested that this is due to the influence of the Coriolis force. According to this proposition the influence of the Coriolis force on a group of masspsychotic animals has been investigated quantitatively. The results suggest the following model: Normally the influence of the Coriolos force, which on the northern hemisphere acts to the right, is compensated by a neuromuscular feedback mechanism. The tendency towards the left under masspsychotic conditions corresponds to overcompensation. The tendency to the left should also be observed on the southern hemisphere, if the direction of this compensation is determined genetically. Therefore, the test proposed by Lemmingson et al. is not suited to distinguish between the influence of the Coriolis force and the influence of biologically active left-isomer molecules.

摘要

莱明森等人观察到,患群体精神病的旅鼠(棕背田鼠)的移动明显偏好向左的方向。他们认为这是由于科里奥利力的影响。根据这一观点,已对科里奥利力对一群患群体精神病动物的影响进行了定量研究。结果表明了以下模型:通常,在北半球向右作用的科里奥利力的影响,会由一种神经肌肉反馈机制进行补偿。在群体精神病状态下向左的倾向对应于过度补偿。如果这种补偿的方向是由基因决定的,那么在南半球也应该观察到向左的倾向。因此,莱明森等人提出的测试并不适合区分科里奥利力的影响和具有生物活性的左旋异构体分子的影响。

相似文献

1
[Physical factors in animal experiments for testing antimasspsychotic drugs].[用于测试抗精神药物的动物实验中的物理因素]
Arzneimittelforschung. 1975 Sep;25(9):1463-5.
2
[An animal test model for evaluating drugs with anti-mass-psychotic activity].
Arzneimittelforschung. 1974 Dec;24(12):2070-3.
3
Influence of nootropic drugs on apomorphine-induced stereotyped behaviour in rats.益智药对大鼠阿扑吗啡诱导的刻板行为的影响。
Biomed Biochim Acta. 1990;49(1):133-6.
4
[Behavior disorder in rats induced by Madopar and its pharmacological correction].[美多芭诱发大鼠行为障碍及其药理学纠正]
Farmakol Toksikol. 1985 Jul-Aug;48(4):31-4.
5
Synthesis and central pharmacological screening of new aminoalkoxy derivatives of coumarin and chromene.香豆素和色烯新氨基烷氧基衍生物的合成及中枢药理筛选
Pol J Pharmacol Pharm. 1992 Sep-Oct;44(5):475-85.
6
[The importance of circadian periodicity factors for the action of psychotropic substances].[昼夜节律因素对精神活性物质作用的重要性]
Farmakol Toksikol. 1984 May-Jun;47(3):13-25.
7
[Antagonism of straightening and stereotyped behavior and of hypothermia induced by 1 or 16 mg/kg-1 of apomorphine].
J Pharmacol. 1983 Jan-Mar;14(1):93-7.
8
[Predicting the psychotropic properties of new drugs on the basis of drug screening in animals].基于动物药物筛选预测新药的精神药物特性
Psychiatr Pol. 1976 Jan-Feb;10(1):33-43.
9
Ethopharmacology; a new way to analyse drug effects on behaviour.行为药理学;一种分析药物对行为影响的新方法。
Triangle. 1982;21(2-3):95-105.
10
[From gene to behavior, a new method for elaboration of new psychotropic agents].
Ann Pharm Fr. 1998;56(2):60-7.