Mao Q W, Zhang L F, Ma J
Department of Aerospace Physiology, The Fourth Military Medical University, Xi'an, China.
Space Med Med Eng (Beijing). 1999 Apr;12(2):92-6.
Objective. The aim of the present study was to test whether medium-sized arteries in different body parts are differentially directed to achieve stimulus-specific remodeling to adapt local hemodynamic changes induced by tail-suspension, and to examine whether these structural changes are reversible. Method. Morphological changes of femoral, anterior tibial, common carotid, and basilar arteries from 4 wk tail-suspended (SUS-4), 1 wk recovered (REC-1), and control (CON) rats were studied using van Gieson-Orcein staining method. Result. For the hindquarter arteries, like the femoral and anterior tibial arteries, the lumen diameter (d) and medial tissue area (A) of SUS-4 group were significantly decreased (P<0.05, P<0.01) as compared with that of CON group, and that of REC-1 group were not fully recovered though the differences were not significant. With respect to arteries in the neck region and the brain, the remodeling changes were just in an opposite direction. In SUS-4 group, the d and A of both common carotid and basilar arteries were significantly increased (P<0.05, P<0.01) as compared with that of CON, and not fully restored after 1 wk recovery. Conclusion. The structures of medium-sized arteries in different body parts remodel differentially in response to local hemodynamic changes during simulated weightlessness and these changes were reversible.
目的。本研究旨在测试不同身体部位的中等大小动脉是否会以不同方式进行重塑，以实现刺激特异性重塑，从而适应尾部悬吊引起的局部血流动力学变化，并研究这些结构变化是否可逆。方法。使用范吉森 - 地衣红染色法研究4周尾部悬吊（SUS - 4）、1周恢复（REC - 1）和对照（CON）大鼠的股动脉、胫前动脉、颈总动脉和基底动脉的形态变化。结果。对于后肢动脉，如股动脉和胫前动脉，SUS - 4组的管腔直径（d）和中膜组织面积（A）与CON组相比显著减小（P<0.05，P<0.01），REC - 1组虽差异不显著但未完全恢复。对于颈部和脑部的动脉，重塑变化方向相反。在SUS - 4组中，颈总动脉和基底动脉的d和A与CON组相比均显著增加（P<0.05，P<0.01），且恢复1周后未完全恢复。结论。在模拟失重期间，不同身体部位的中等大小动脉结构会因局部血流动力学变化而发生不同程度的重塑，且这些变化是可逆的。
