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红豆杉(欧洲红豆杉)树叶致死性中毒(作者译)

[Lethal intoxication with leaves of the yew tree (Taxus baccata) (author's transl)].

作者信息

Schulte T

出版信息

Arch Toxicol. 1975 Oct 20;34(2):153-8. doi: 10.1007/BF00353316.

DOI:10.1007/BF00353316
PMID:1242888
Abstract

A case of a rare lethal intoxication with yew leaves (taxus baccata) is reported. The clinical signs were dizziness (onset 1 hr after yew leaves were ingested), nausea, diffuse abdominal pain, unconsciousness, weak breathing, tachycardia, brief ventricular flutter afterwards a slow pulse, and finally death by respiratory arrest and diastolic cardiac standstill. Particular attention was given to the ECG. It showed an atypical bundle branch block with a maximal QRS-duration of 0.24 sec. A striking resemblence to the ECG in the case of hyperkalemia is seen in that P-waves were absent. Therefore, the possibility is noted that an acute hyperkalemia could be partly responsible for the cardiotoxic effect of the leaf.

摘要

报告了一例罕见的致命性红豆杉叶中毒病例。临床症状为头晕(摄入红豆杉叶后1小时发作)、恶心、弥漫性腹痛、昏迷、呼吸微弱、心动过速、随后出现短暂室性扑动及脉搏缓慢,最终因呼吸骤停和舒张期心脏停搏死亡。特别关注了心电图。心电图显示非典型束支传导阻滞,最大QRS时限为0.24秒。与高钾血症病例的心电图有显著相似之处,即P波消失。因此,注意到急性高钾血症可能部分导致了树叶的心脏毒性作用。

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本文引用的文献

1
[A fatal case of poisoning with Taxus baccata. Experiments on demonstration of Taxus alkaloid in the cadaver organs].[一例欧洲红豆杉中毒致死病例。在尸体器官中检测红豆杉生物碱的实验]
Arch Toxikol. 1960;18:88-92.
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[Pharmacological properties of taxins A and B].
Arzneimittelforschung. 1959 Jan;9(1):77-9.
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[Amorphous taxine & crystalline taxine A; Taxus alkaloids. II].[无定形紫杉碱与结晶型紫杉碱A;红豆杉生物碱。II]
Pharm Zentralhalle Dtschl. 1957 Aug-Sep;96(8-9):385-95.
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Suicidal yew leave ingestion--phloroglucindimethylether (3,5-dimethoxyphenol) as a marker for poisoning from Taxus baccata.自杀性摄入紫杉树叶——间苯三酚二甲醚(3,5 - 二甲氧基苯酚)作为欧洲红豆杉中毒的标志物
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Cardiovascular toxicity associated with yew leaf ingestion.与摄入紫杉叶相关的心血管毒性。
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4
[Study on beta-dimethylamino-hydrozimt acid].[β-二甲基氨基-氢嗪酸的研究]
Arch Pharm Ber Dtsch Pharm Ges. 1956 Jul;289/61(7):364-70. doi: 10.1002/ardp.19562890707.
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[Fatal poisoning with Taxus baccata].[欧洲红豆杉致死性中毒]
Arch Toxikol. 1965;21(3):150-62. doi: 10.1007/BF02340557.