自杀性摄入紫杉树叶——间苯三酚二甲醚（3,5 - 二甲氧基苯酚）作为欧洲红豆杉中毒的标志物
Suicidal yew leave ingestion--phloroglucindimethylether (3,5-dimethoxyphenol) as a marker for poisoning from Taxus baccata.
作者信息
Musshoff F, Jacob B, Fowinkel C, Daldrup T
机构信息
Institute of Legal Medicine, Heinrich Heine University, Düsseldorf, Germany.
出版信息
Int J Legal Med. 1993;106(1):45-50. doi: 10.1007/BF01225024.
In a case of suicide in a depressive 19-year-old man with considerable ingestion of new leaves, resorption of yew ingredients could be demonstrated. The main substance could be identified as 3,5-dimethoxyphenol, the aglycone of taxicatine, which is a typical ingredient of yew leaves. 3,5-dimethoxyphenol was demonstrated in harvested yew leaves, stomach content and cardiac blood of the victim. Structure confirmation was achieved by means of HPLC, UV, GC-MS, IR and 1H-NMR spectroscopy. None of the Taxus alkoids could be identified. The components detected by TLC have not yet been identified. The results demonstrate that 3,5-dimethoxyphenol can be used as a marker in cases of intoxication by yew ingredients.
在一名19岁患有抑郁症的男子自杀案例中，该男子大量摄入了新采摘的紫杉树叶，结果证实紫杉成分被吸收。主要物质可鉴定为3,5 - 二甲氧基苯酚，即紫杉亭的糖苷配基，它是紫杉树叶的典型成分。在受害者采摘的紫杉树叶、胃内容物和心脏血液中均检测到了3,5 - 二甲氧基苯酚。通过高效液相色谱法（HPLC）、紫外光谱法（UV）、气相色谱 - 质谱联用法（GC - MS）、红外光谱法（IR）和氢核磁共振光谱法（1H - NMR）对其结构进行了确认。未鉴定出任何紫杉生物碱。薄层色谱法（TLC）检测到的成分尚未得到鉴定。结果表明，3,5 - 二甲氧基苯酚可作为紫杉成分中毒案例的标志物。
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