Tjioe M, Gerritsen M J P, Juhlin L, van de Kerkhof P C M
Department of Dermatology, University Medical Center Nijmegen, The Netherlands.
Acta Derm Venereol. 2002;82(5):369-72. doi: 10.1080/000155502320624113.
Narrow band UVB is succeeding psoralen and UVA irradiation as the main treatment of vitiligo vulgaris in several European countries. Vitamin B12 and folic acid deficiency in some vitiligo patients has prompted researchers to investigate the efficacy of these vitamins in the treatment of vitiligo. In the present controlled study we investigated the value of narrow band UVB phototherapy in the treatment of vitiligo and the possible additive effect of vitamin B12 and folic acid. Twenty-seven patients with long-term stable vitiligo were included and randomized in a "UVB only" (UVB) or "UVB combined with vitamin B12 and folic acid" (UVB+) group. Patients were irradiated thrice weekly for one year, whilst repigmentation was carefully monitored. In 92% (25/27) of the patients up to 100% repigmentation was seen. Repigmentation was notable in lesions on the face, neck and throat, lower arm, chest, back and lower legs, whilst repigmentation on the hands, wrists, feet and ankles proved to be minimal. Maximum repigmentation rates did not differ significantly between the UVB group and the UVB+ group. Our study reconfirms that narrow band UVB phototherapy is an effective treatment for vitiligo and shows that co-treatment with vitamin B12 and folic acid does not improve the outcome of treatment of vitiligo with narrow band UVB phototherapy.
在几个欧洲国家，窄谱中波紫外线（NB-UVB）正逐渐取代补骨脂素加紫外线A（PUVA）照射，成为寻常型白癜风的主要治疗方法。一些白癜风患者存在维生素B12和叶酸缺乏的情况，这促使研究人员探究这些维生素在白癜风治疗中的疗效。在本对照研究中，我们调查了窄谱中波紫外线光疗在白癜风治疗中的价值以及维生素B12和叶酸可能的附加作用。纳入27例长期病情稳定的白癜风患者，并将其随机分为“仅接受窄谱中波紫外线治疗”（UVB组）或“窄谱中波紫外线联合维生素B12和叶酸治疗”（UVB+组）。患者每周接受3次照射，为期1年，同时仔细监测色素再生情况。92%（25/27）的患者出现了高达100%的色素再生。面部、颈部、喉部、下臂、胸部、背部和小腿的皮损色素再生明显，而手部、腕部、足部和踝部的色素再生极少。UVB组和UVB+组的最大色素再生率差异无统计学意义。我们的研究再次证实，窄谱中波紫外线光疗是治疗白癜风的有效方法，且表明维生素B12和叶酸联合治疗并不能改善窄谱中波紫外线光疗对白癜风的治疗效果。
