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对工业γ射线探伤源严重过度照射的细胞遗传学调查。

Cytogenic investigations of serious overexposures to an industrial gamma radiography source.

作者信息

Sevan'kaev A V, Lloyd D C, Edwards A A, Moquet J E, Nugis V Yu, Mikhailova G M, Potetnya O I, Khvostunov I K, Guskova A K, Baranov A E, Nadejina N M

机构信息

Medical Radiological Research Centre of RAMS, Obninsk, Kaluga Region, Russia.

出版信息

Radiat Prot Dosimetry. 2002;102(3):201-6. doi: 10.1093/oxfordjournals.rpd.a006090.

DOI:10.1093/oxfordjournals.rpd.a006090
PMID:12430960
Abstract

This paper describes the sequence of events, medical aspects and dose estimations for two radiographers and their driver who were seriously exposed to an iridium-192 industrial radiography source that became detached from its wind-out cable. The men came to medical attention about 1 month later by which time all three were severely leucopenic and one had skin burns on both hands. Doses were estimated by (i) physics calculations combined with their accounts of the event. (ii) the levels of depression of their blood neutrophils, (iii) electron spin resonance on tooth enamel and (iv) blood lymphocyte chromosomal analyses by the conventional dicentric and the fluorescence in situ hybridisation methods. Intercomparison of these methods for estimating doses showed a good level of agreement. In brief, the averaged whole body dose for the most seriously exposed man was about 2.5-3.0 Gy and for the others it was 1.0-2.0 Gy.

摘要

本文描述了两名放射技师及其司机严重暴露于从放线电缆脱落的铱 - 192工业射线照相源的事件过程、医学情况及剂量估算。这三人在约1个月后就医,此时三人都严重白细胞减少,其中一人双手有皮肤灼伤。剂量通过以下方法估算:(i)物理计算结合他们对事件的描述;(ii)他们血液中性粒细胞的减少水平;(iii)牙釉质的电子自旋共振;(iv)采用传统双着丝粒和荧光原位杂交方法进行血液淋巴细胞染色体分析。这些剂量估算方法的相互比较显示出良好的一致性。简而言之,暴露最严重的男子平均全身剂量约为2.5 - 3.0 Gy,其他两人为1.0 - 2.0 Gy。

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