Rapoff Michael A, Belmont John, Lindsley Carol, Olson Nancy, Morris Judy, Padur Joni
Department of Pediatrics, University of Kansas Medical Center, Kansas City 66160-7330, USA.
Health Psychol. 2002 Nov;21(6):620-3. doi: 10.1037//0278-6133.21.6.620.
Adherence to medications for chronic pediatric diseases decreases overtime. This randomized controlled trial evaluated a clinic-based, nurse-administered educational and behavioral intervention to prevent the anticipated drop in adherence to nonsteroidal medications among newly diagnosed patients with juvenile rheumatoid arthritis. Thirty-four participants completed the study (mean age = 8.44 years, SD = 3.96), including 19 in the experimental group and 15 in the standard-treatment (education) control group. There were significant group and Group x Time effects for adherence (assessed with an electronic monitor over a 13-month period) favoring the experimental group. In contrast, the groups did not differ significantly in disease activity or functional limitations. Factors that may have prevented detection of differences in these health parameters are dicussed.
慢性儿科疾病药物治疗的依从性会随时间下降。这项随机对照试验评估了一种基于诊所、由护士实施的教育和行为干预措施，以预防新诊断的青少年类风湿性关节炎患者对非甾体类药物依从性的预期下降。34名参与者完成了研究（平均年龄 = 8.44岁，标准差 = 3.96），其中19名在实验组，15名在标准治疗（教育）对照组。在依从性方面（通过电子监测器在13个月期间进行评估）存在显著的组间和组×时间效应，有利于实验组。相比之下，两组在疾病活动或功能受限方面没有显著差异。讨论了可能阻碍检测这些健康参数差异的因素。
