King Bruce M, Cook Jack T, Rossiter Kirk N, Rollins Bethany L
Department of Psychology, University of New Orleans, New Orleans, Louisiana 70148, USA.
Am J Physiol Regul Integr Comp Physiol. 2003 Apr;284(4):R965-82. doi: 10.1152/ajpregu.00249.2002. Epub 2002 Nov 14.
Small lesions centered in the posterodorsal region of the medial amygdala resulted in excessive weight gains in female rats. Unilateral lesions were nearly as effective as bilateral lesions in the first 48 h after surgery (+21 to +32 g). Assessment of lesion damage was done by both qualitative evaluation and by a quantitative grid-point counting method. The critical sites for weight gain were the intra-amygdaloid bed nucleus of the stria terminalis and the posterodorsal medial amygdaloid nucleus. Incidental damage to the overlying globus pallidus was negatively related to weight gain. The cupric silver method for demonstrating axonal degeneration was applied to brains with obesity-inducing lesions. A dense pattern of degenerating terminals was found in the lateral septum, amygdala, ventral striatum, and ventromedial hypothalamus. Degeneration in the paraventricular nucleus of the hypothalamus was scarce or absent. Small retrograde tracer injections made in either the intra-amygdaloid bed nucleus of the stria terminalis or in the posterodorsal medial amygdaloid nucleus labeled cells in the amygdala, lateral septum, and hypothalamus, reciprocating the anterograde projections from the amygdala to these areas. The data suggest that subdivisions of the posterodorsal amygdala participate in the regulation of feeding in a manner that is similar to the better-known role of this part of the brain in mediating reproductive behavior. Although topographical differences may exist within the amygdaloid and hypothalamic subdivisions regulating these two sexually dimorphic behaviors, the relays engaged by feeding-related connections and those related to reproduction are remarkably parallel.
位于内侧杏仁核后背部区域的小损伤导致雌性大鼠体重过度增加。单侧损伤在手术后的头48小时内几乎与双侧损伤一样有效（体重增加21至32克）。通过定性评估和定量网格点计数法对损伤情况进行评估。体重增加的关键部位是终纹床核杏仁体内侧部和后背部内侧杏仁核。上方苍白球的附带损伤与体重增加呈负相关。将用于显示轴突退变的铜银法应用于具有致肥胖损伤的大脑。在外侧隔、杏仁核、腹侧纹状体和腹内侧下丘脑发现了密集的退变终末模式。下丘脑室旁核的退变很少或不存在。在终纹床核杏仁体内侧部或后背部内侧杏仁核进行的小逆行示踪剂注射标记了杏仁核、外侧隔和下丘脑的细胞，这与杏仁核到这些区域的顺行投射相互对应。数据表明，后背部杏仁核的亚区以类似于大脑这一部分在介导生殖行为中所起的更为人熟知的作用的方式参与进食调节。尽管在调节这两种性别二态性行为的杏仁核和下丘脑亚区内可能存在地形差异，但与进食相关的连接和与生殖相关的连接所涉及的中继非常平行。
