具有封闭γ-磷酸基团的ATP类似物与人类红细胞钠泵的相互作用。
The interaction of ATP-analogues possessing a blocked gamma-phosphate group with the sodium pump in human red cells.
作者信息
Simons T J
出版信息
J Physiol. 1975 Jan;244(3):731-9. doi: 10.1113/jphysiol.1975.sp010822.
Abstract
- The (Na++K+)-ATPase of red cell membranes is unable to hydrolyse ATP-analogues in which the oxygen atom linking the beta- and gamma-phosphate groups is replaced by a minusCH2minus or minusNH-bridge. 2. In resealed ghosts both these ATP-analogues support K:K exchange but not Na:K exchange. ATP supports both modes of operation of the sodium pump, whereas neither occurs without any nucleotide. 3. These results support the hypothesis that ATP is needed as a cofactor for K:K exchange to occur, and make it extremely unlikely that phosphorylation from ATP is involved.
摘要
- 红细胞膜的（钠+钾）-ATP酶无法水解β-和γ-磷酸基团之间的氧原子被-CH2-或-NH-桥取代的ATP类似物。2. 在重封的血影中，这两种ATP类似物都支持钾：钾交换，但不支持钠：钾交换。ATP支持钠泵的两种运作模式，而没有任何核苷酸时则两种模式都不会发生。3. 这些结果支持了这样的假设，即ATP作为钾：钾交换发生的辅助因子是必需的，并且极不可能涉及由ATP进行的磷酸化。
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The catalytic effect of molybdate on the hydrolysis of organic phosphate bonds.钼酸盐对有机磷酸酯键水解的催化作用。
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Reversal of the potassium entry mechanism in red cells, with and without reversal of the entire pump cycle.红细胞中钾离子进入机制的逆转，无论整个泵循环是否逆转。
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The uncoupled extrusion of Na+ through the Na+ pump.
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