患有动脉粥样硬化疾病特定表现的患者血清中弹性蛋白衍生肽的浓度。
Serum concentrations of elastin-derived peptides in patients with specific manifestations of atherosclerotic disease.
作者信息
Petersen E, Wågberg F, Angquist K-A
机构信息
Department of Surgery, Umeå University Hospital, Umeå, Sweden.
出版信息
Eur J Vasc Endovasc Surg. 2002 Nov;24(5):440-4. doi: 10.1053/ejvs.2002.1750.
OBJECTIVE
To measure serum concentrations of elastin-derived peptides (S-EDP) in patients with aneurysmal, occlusive and ulcerative manifestations of atherosclerotic disease.
MATERIALS AND METHODS
S-EDP concentrations were measured by a competitive enzyme-linked immunosorbent assay in 10 patients with infrarenal aneurysms 5cm in diameter (AAA), 10 patients with distal aortic occlusive disease (AOD), 10 patients with symptomatic carotid stenosis (>or=70%) and plaque ulceration (SCS) and a control group of 10 patients with no similar specific manifestations of atherosclerotic disease (NAM).
RESULTS
S-EDP concentrations (median, range) were significantly higher in patients with AAA (42ng/ml, 35-52, p<0.001) and SCS (49ng/ml, 37-60, p<0.001) but not AOD (28ng/ml, 22-38, p=0.240) compared to NAM (26ng/ml, 19-36) patients.
CONCLUSION
Increased concentrations of S-EDP were associated with aneurysmal and ulcerative, but not occlusive, manifestations of atherosclerosis.
目的
测定患有动脉粥样硬化疾病的动脉瘤、闭塞性和溃疡性表现患者的血清弹性蛋白衍生肽（S-EDP）浓度。
材料与方法
采用竞争性酶联免疫吸附测定法，对10例直径5cm的肾下腹主动脉瘤（AAA）患者、10例远端主动脉闭塞性疾病（AOD）患者、10例有症状的颈动脉狭窄（≥70%）且斑块溃疡（SCS）患者以及10例无动脉粥样硬化疾病类似特定表现（NAM）的对照组患者进行S-EDP浓度测定。
结果
与NAM（26ng/ml，19 - 36）患者相比，AAA患者（42ng/ml，35 - 52，p<0.001）和SCS患者（49ng/ml，37 - 60，p<0.001）的S-EDP浓度（中位数，范围）显著更高，但AOD患者（28ng/ml，22 - 38，p = 0.240）并非如此。
结论
S-EDP浓度升高与动脉粥样硬化的动脉瘤和溃疡性表现相关，但与闭塞性表现无关。
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