Petersen E, Wågberg F, Angquist K-A
Department of Surgery, Umeå University Hospital, Umeå, Sweden.
Eur J Vasc Endovasc Surg. 2002 Nov;24(5):440-4. doi: 10.1053/ejvs.2002.1750.
To measure serum concentrations of elastin-derived peptides (S-EDP) in patients with aneurysmal, occlusive and ulcerative manifestations of atherosclerotic disease.
S-EDP concentrations were measured by a competitive enzyme-linked immunosorbent assay in 10 patients with infrarenal aneurysms 5cm in diameter (AAA), 10 patients with distal aortic occlusive disease (AOD), 10 patients with symptomatic carotid stenosis (>or=70%) and plaque ulceration (SCS) and a control group of 10 patients with no similar specific manifestations of atherosclerotic disease (NAM).
S-EDP concentrations (median, range) were significantly higher in patients with AAA (42ng/ml, 35-52, p<0.001) and SCS (49ng/ml, 37-60, p<0.001) but not AOD (28ng/ml, 22-38, p=0.240) compared to NAM (26ng/ml, 19-36) patients.
Increased concentrations of S-EDP were associated with aneurysmal and ulcerative, but not occlusive, manifestations of atherosclerosis.
测定患有动脉粥样硬化疾病的动脉瘤、闭塞性和溃疡性表现患者的血清弹性蛋白衍生肽（S-EDP）浓度。
采用竞争性酶联免疫吸附测定法，对10例直径5cm的肾下腹主动脉瘤（AAA）患者、10例远端主动脉闭塞性疾病（AOD）患者、10例有症状的颈动脉狭窄（≥70%）且斑块溃疡（SCS）患者以及10例无动脉粥样硬化疾病类似特定表现（NAM）的对照组患者进行S-EDP浓度测定。
与NAM（26ng/ml，19 - 36）患者相比，AAA患者（42ng/ml，35 - 52，p<0.001）和SCS患者（49ng/ml，37 - 60，p<0.001）的S-EDP浓度（中位数，范围）显著更高，但AOD患者（28ng/ml，22 - 38，p = 0.240）并非如此。
S-EDP浓度升高与动脉粥样硬化的动脉瘤和溃疡性表现相关，但与闭塞性表现无关。
