Tarrerias A L, Millecamps M, Alloui A, Beaughard C, Kemeny J L, Bourdu S, Bommelaer G, Eschalier A, Dapoigny M, Ardid D
Service de Gastro-Entérologie, Hotel-Dieu, 63000 Clermont-Ferrand, France.
Pain. 2002 Nov;100(1-2):91-7. doi: 10.1016/s0304-3959(02)00234-8.
Short-chain fatty acid (SCFA) (especially butyrate) enemas are widely used to reduce symptoms associated with human inflammatory bowel disease. The purpose of this study was to evaluate their real effect on colonic sensitivity in rats.
The effects of saline and SCFA enemas (acetate, propionate and particularly butyrate) were studied on visceral pain thresholds following colonic distension in control rats and in rats with colitis (instilled with trinitrobenzene sulfonic acid (TNBS)).
Butyrate enemas (40 mM twice daily for 14 days) decreased colonic pain thresholds in control rats; they did not reduce the TNBS-induced hypersensitivity, but on the contrary increased its duration (without modifying the inflammation score). This pronociceptive effect was confirmed in control rats receiving twice daily enemas of 80 mM for 3 days and two enemas of 240 mM of a butyrate solution. The other SCFA enemas did not modify the hypersensitivity of rats with colitis and induced proinflammatory effects.
The beneficial effect of SCFA (especially butyrate) enemas on hypersensitivity and inflammation in inflammatory bowel disease is questionable and needs to be thoroughly investigated in humans.
短链脂肪酸（SCFA）（尤其是丁酸盐）灌肠剂被广泛用于减轻与人类炎症性肠病相关的症状。本研究的目的是评估它们对大鼠结肠敏感性的实际影响。
研究了生理盐水和SCFA灌肠剂（乙酸盐、丙酸盐，特别是丁酸盐）对正常大鼠和结肠炎大鼠（用三硝基苯磺酸（TNBS）灌注）结肠扩张后内脏痛阈的影响。
丁酸盐灌肠剂（40 mM，每日两次，共14天）降低了正常大鼠的结肠痛阈；它们并未减轻TNBS诱导的超敏反应，反而延长了其持续时间（未改变炎症评分）。在每日接受两次80 mM灌肠剂共3天以及两次240 mM丁酸盐溶液灌肠的正常大鼠中证实了这种促痛觉效应。其他SCFA灌肠剂并未改变结肠炎大鼠的超敏反应，并产生了促炎作用。
SCFA（尤其是丁酸盐）灌肠剂对炎症性肠病超敏反应和炎症的有益作用值得怀疑，需要在人体中进行深入研究。
