传染性牛鼻气管炎痘苗病毒感染的胸苷激酶缺陷型LM细胞中胸苷激酶合成的调控
Control of thymidine kinase synthesis in IHD vaccinia virus-infected thymidine kinase-deficient LM cells.
作者信息
Zaslavsky V, Yakobson E
出版信息
J Virol. 1975 Jul;16(1):210-3. doi: 10.1128/JVI.16.1.210-213.1975.
Abstract
The synthesis of vaccinia virus-induced thymidine kinase is normally arrested several hours after infection. In thymidine kinase-deficient LM cells infected with IHD strain of vaccinia virus, arrest occurs whether or not viral DNA synthesis is inhibited. With virus inactivated by UV irradiation, enzyme synthesis takes place, but arrest is abolished. It is suggested that an early viral genetic function is responsible for the cessation of thymidine kinase synthesis.
摘要
痘苗病毒诱导的胸苷激酶的合成通常在感染后数小时停止。在用痘苗病毒IHD株感染的胸苷激酶缺陷型LM细胞中，无论病毒DNA合成是否受到抑制，都会出现停止现象。用紫外线照射使病毒失活后，酶的合成仍会发生，但停止现象消失。提示病毒早期遗传功能与胸苷激酶合成的停止有关。
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