锌离子对痘苗病毒生长的抑制作用：对早期RNA和胸苷激酶合成的影响。
Inhibition of vaccinia virus growth by zinc ions: effects on early RNA and thymidine kinase synthesis.
作者信息
Zaslavsky V
出版信息
J Virol. 1979 Jan;29(1):405-8. doi: 10.1128/JVI.29.1.405-408.1979.
Abstract
Accumulation of thymidine kinase activity in vaccinia virus-infected cells was severely inhibited by zinc ions if the drug was added within 1 h postinfection. If added later, zinc ions had no effect on the enzyme synthesis. A fraction of RNA which is normally synthesized in infected cells, was missing from a proper part of the gradient if the cells were treated with zinc ions within 1 h postinfection (as has been shown by cosedimentation of pulse-labeled RNAs in isokinetic gradients). It is suggested that a transcriptional (or posttranscriptional) step is involved in zinc-caused inhibition of vaccinia virus growth.
摘要
如果在感染后1小时内添加锌离子，锌离子会严重抑制痘苗病毒感染细胞中胸苷激酶活性的积累。如果稍后添加，锌离子对该酶的合成没有影响。如果在感染后1小时内用锌离子处理细胞，感染细胞中正常合成的一部分RNA在梯度的适当部分会缺失（如脉冲标记RNA在等密度梯度中共沉降所显示）。提示锌导致痘苗病毒生长抑制涉及转录（或转录后）步骤。
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1
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Virology. 1963 Nov;21:383-9. doi: 10.1016/0042-6822(63)90199-5.
2
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Exp Cell Res. 1963 Aug;31:297-312. doi: 10.1016/0014-4827(63)90007-7.
3
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Virology. 1962 Sep;18:9-18. doi: 10.1016/0042-6822(62)90172-1.
4
Induction of thymidine kinase by vaccinia-infected mouse fibroblasts.痘苗病毒感染的小鼠成纤维细胞诱导胸苷激酶的产生。
J Mol Biol. 1963 Jan;6:22-33. doi: 10.1016/s0022-2836(63)80078-9.
5
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6
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