Guinot Christiane, Malvy Denis J-M, Ambroisine Laurence, Latreille Julie, Mauger Emmanuelle, Tenenhaus Michel, Morizot Frédérique, Lopez Sabine, Le Fur Isabelle, Tschachler Erwin
C.E.R.I.E.S., Neuilly-sur-Seine, France.
Arch Dermatol. 2002 Nov;138(11):1454-60. doi: 10.1001/archderm.138.11.1454.
To assess the relative contribution of intrinsic aging vs lifestyle factors to facial skin age.
Prospective analysis of a cohort.
Skin research institute.
A cohort of 361 white women (age range, 18-80 years) with apparently healthy skin.
Visual and tactile assessment of facial skin features.
Twenty-four skin characteristics were used to build a skin age score (SAS). The relationship between the SAS and chronological age followed a linear model with 2 plateaus--1 before age 30 years and 1 after age 71 years. An analysis was performed to determine whether certain lifestyle habits known to have effects on skin aging were related to the discrepancies between chronological age and the SAS. Significant effects were identified for phototype, body mass index, menopausal status, degree of lifetime sun exposure, and number of years of cigarette smoking. However, these factors accounted for only 10% of the discrepancies. Moreover, most skin characteristics used reflected changes understood to represent intrinsic aging rather than photodamage or other extrinsic factors.
An SAS can be generated from multiple discrete signs evaluated on facial skin and is an informative tool for quantifying skin aging. The SAS is influenced by factors already recognized to affect the aging phenotypes; however, factors related to the rate of intrinsic aging, presumably genetic in character, seem to play a larger role than previously suspected.
评估内在衰老与生活方式因素对面部皮肤年龄的相对影响。
对一组人群进行前瞻性分析。
皮肤研究所。
361名面部皮肤看似健康的白人女性（年龄范围18 - 80岁）。
对面部皮肤特征进行视觉和触觉评估。
使用24种皮肤特征构建皮肤年龄评分（SAS）。SAS与实际年龄之间的关系遵循线性模型，有两个平稳阶段，一个在30岁之前，另一个在71岁之后。进行了一项分析，以确定某些已知对皮肤衰老有影响的生活习惯是否与实际年龄和SAS之间的差异有关。发现光类型、体重指数、绝经状态、终生日晒程度和吸烟年数有显著影响。然而，这些因素仅占差异的10%。此外，所使用的大多数皮肤特征反映的变化被认为代表内在衰老，而非光损伤或其他外在因素。
可以根据对面部皮肤评估的多个离散体征生成SAS，它是量化皮肤衰老的一个有用工具。SAS受已确认影响衰老表型的因素影响；然而，与内在衰老速度相关的因素（可能具有遗传性质）似乎比之前怀疑的发挥着更大作用。
