Chung Jin Ho, Yano Kiichiro, Lee Mi Kyung, Youn Choon Shik, Seo Jin Young, Kim Kyu Han, Cho Kwang Hyun, Eun Hee Chul, Detmar Michael
Department of Dermatology, Seoul National University College of Medicine, Clinical Research Institute, Seoul National University Hospital, Chongno-Gu, Korea.
Arch Dermatol. 2002 Nov;138(11):1437-42. doi: 10.1001/archderm.138.11.1437.
To quantify the distinct effects of photoaging vs intrinsic aging of human skin on cutaneous vascularization in the Korean population.
Case series.
University hospital.
A total of 21 healthy Korean volunteers from the third to the ninth decades of life.
Skin biopsy specimens were obtained from chronically sun-exposed and sun-protected skin of each participant.
Frozen sections were stained for the platelet endothelial cell adhesion molecule CD31 (PECAM-1), and computer-assisted quantitative image analysis was performed to quantify cutaneous vascular density and vessel size.
Intrinsically aged and photoaged skin showed an age-dependent reduction of cutaneous vessel size. However, only photoaged skin exhibited significantly reduced numbers of dermal vessels, in particular in the subepidermal areas that displayed extensive matrix damage. Linear regression analysis revealed an inverse relation of vessel numbers and age in sun-damaged, but not in sun-protected, skin.
In Korean skin, chronic photodamage results in a gradual decrease in the number and size of dermal vessels over several decades of sun exposure, most likely due to degenerative changes of the dermal extracellular matrix. Because the present investigation was restricted to ethnic Korean volunteers, future studies are needed to evaluate whether similar changes can be observed in whites.
量化韩国人群中光老化与自然老化对皮肤血管化的不同影响。
病例系列研究。
大学医院。
共有21名年龄在三十至九十岁之间的健康韩国志愿者。
从每位参与者长期暴露于阳光和受到防晒保护的皮肤中获取皮肤活检标本。
对冰冻切片进行血小板内皮细胞黏附分子CD31（PECAM-1）染色，并采用计算机辅助定量图像分析来量化皮肤血管密度和血管大小。
自然老化和光老化的皮肤均显示出与年龄相关的皮肤血管大小减小。然而，只有光老化的皮肤真皮血管数量显著减少，尤其是在显示出广泛基质损伤的表皮下区域。线性回归分析显示，在受阳光损伤的皮肤中血管数量与年龄呈负相关，而在受防晒保护的皮肤中则不然。
在韩国人的皮肤中，长期光损伤会导致在数十年的阳光暴露过程中真皮血管数量和大小逐渐减少，这很可能是由于真皮细胞外基质的退行性变化所致。由于本研究仅限于韩国志愿者，未来需要开展研究以评估在白人中是否能观察到类似变化。
