Shakhnovich Elizabeth A, King Samantha J, Weiser Jeffrey N
Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA.
Infect Immun. 2002 Dec;70(12):7161-4. doi: 10.1128/IAI.70.12.7161-7164.2002.
Both Neisseria meningitidis and Haemophilus influenzae are capable of mimicking host structures by decorating their lipopolysaccharides with sialic acid. We show that a neuraminidase expressed by Streptococcus pneumoniae (NanA) is able to desialylate the cell surfaces of both these species, which reside in and possibly compete for the same host niche.
脑膜炎奈瑟菌和流感嗜血杆菌都能够通过用唾液酸修饰其脂多糖来模拟宿主结构。我们发现,肺炎链球菌表达的一种神经氨酸酶(NanA)能够去除这两种细菌的细胞表面唾液酸,这两种细菌存在于相同的宿主生态位中且可能相互竞争。