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肺炎链球菌表达的神经氨酸酶可去除脑膜炎奈瑟菌和流感嗜血杆菌脂多糖上的唾液酸:人类呼吸道病原体间细菌竞争的范例

Neuraminidase expressed by Streptococcus pneumoniae desialylates the lipopolysaccharide of Neisseria meningitidis and Haemophilus influenzae: a paradigm for interbacterial competition among pathogens of the human respiratory tract.

作者信息

Shakhnovich Elizabeth A, King Samantha J, Weiser Jeffrey N

机构信息

Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA.

出版信息

Infect Immun. 2002 Dec;70(12):7161-4. doi: 10.1128/IAI.70.12.7161-7164.2002.

Abstract

Both Neisseria meningitidis and Haemophilus influenzae are capable of mimicking host structures by decorating their lipopolysaccharides with sialic acid. We show that a neuraminidase expressed by Streptococcus pneumoniae (NanA) is able to desialylate the cell surfaces of both these species, which reside in and possibly compete for the same host niche.

摘要

脑膜炎奈瑟菌和流感嗜血杆菌都能够通过用唾液酸修饰其脂多糖来模拟宿主结构。我们发现,肺炎链球菌表达的一种神经氨酸酶(NanA)能够去除这两种细菌的细胞表面唾液酸,这两种细菌存在于相同的宿主生态位中且可能相互竞争。

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本文引用的文献

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